eISSN: 1734-4948
ISSN: 0860-6161
Advances in Rehabilitation
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vol. 35
Original paper

Effect of aerobic exercise training on leptin and liver enzymes in non-diabetic overweight hepatitis C men

Ali Mohamed Ali Ismail
Ahmed Mahmoud Nasr Tolba
El-Sayed Essam El-Sayed Felaya

Department of Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt
Basic Science Department, Faculty of Physical Therapy, Delta University for Science and Technology, International Coastal Road, Gamassa, Dakahlia, Egypt
Advances in Rehabilitation, 2021, 35(2), 17–23
Online publish date: 2021/05/13
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Leptin is one of the new adipokines that reflects the pathological status of liver tissue in the chronic hepatitis C virus (HCV). This study aimed to investigate the leptin and liver enzymes responses to aerobic exercise (AE) in overweight nondiabetics with HCV.

Material and methods
Forty nondiabetic non-cirrhotic HCV men aged 40-60 years old with a body mass index (BMI) varied from 25 - 29.9 Kg/m2 were divided randomly to study and control groups. The study group (n = 20) received a 3-session continuous moderateintensity AE per week for 12 weeks while the control group (n = 20) were advised to maintain their normal level of physical activity. Pre and post measurements of weight, BMI, waist circumference, fasting blood glucose (FBG), alanine transaminase (ALT), aspartate transaminase (AST), and leptin were measured for all forty patients.

Statistical ANOVA analysis revealed a post-treatment significant statistical decrease of all variables within the study group (p < 0.05) while the control group showed a nonsignificant difference of all measurements. Post-treatment between-group analysis showed a significant statistical difference in FBG, ALT, AST, and leptin in favor of the study group.

To restore the normal hepatic cellular functions and to prevent HCV-induced hepatic fibrosis, AE is a strong therapeutic modality that lowers leptin levels via weight maintenance and/or loss, increased glucose uptake, and declined liver enzymes.


Overweight, Aerobic exercise, Leptin, Liver enzymes, Hepatitis C

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